GenomeSignature: Homologous Recombination Deficiency (HRD) Score assay

A predictive biomarker to targeted therapy with PARP inhibitors.

Assessment of Genomic Instability using three biomarkers: Loss of Heterozygosity (LOH), Telomeric Allelic Imbalance(NtAI) & Large-scale State Transitions (LST).

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GenomeSignature
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Tumors manifesting HRD are especially sensitive to PARP inhibitors, as these agents increase the number of double stranded breaks, making cell death more likely in cells also manifesting HRD. Therefore, HRD and the presence of HRR gene mutations have become biomarkers for assessing PARP inhibitor sensitivity.”

Genomic Instability Score

Homologous Recombination Deficiency is calculated by proprietary algorithm developed at Rophevac Bio Labz based on three biomarkers (loss of heterozygosity, telomeric allelic imbalance and large-scale state transitions).

HRR Pathway Genes

GenomeSignature assay Includes Somatic and Germline analysis for the presence of specific mutations within BRCA1, BRCA2 along with HRR pathway genes, (Total 28 genes) at high depth using Next Generation Sequencing.

BRCA1 & BRCA2 MLPA

GenomeSignature assay Includes BRCA1 and BRCA2 Germline study to analyse deletion/duplications. intended to confirm a potential cause for and clinical diagnosis of hereditary breast and ovarian cancer (HBOC) syndrome.

Most Causes of HRD are Unknown

Ovarian and breast tumors with loss of either BRCA1 or BRCA2 are particularly sensitive to treatment with platinum-based DNA crosslinking agents.

Some tumors with no apparent loss of BRCA1 or BRCA2 exhibit similar patterns of genomic scars, and also show increased sensitivity to treatment with platinum drugs. This suggests that defects in DNA repair other than BRCA1 or BRCA2 loss may also confer drug sensitivities similar to BRCA1/2 loss.

HRD describes a tumor that has an impaired ability to repair DNA double strand breaks through homologous recombination repair.

The GenomeSignature assay is designed to identify a comprehensive signature for Homologous Recombination Deficiency (HRD) by testing genome-wide single nucleotide variants in DNA extracted from FFPE tumor specimens.

Clinical and Therapeutic significance of HRD

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Identify more potentially eligible patients sensitive to PARP inhibitors

Positive patients by Testing Modality

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HRR pathway genes covered in Panel

Germline + Somatic Study

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State of the art Bioinformatics pipelines
As the patterns of genomic scars may be DNA repair pathway-specific rather than gene-specific, drug response signatures based on genomic scars may be reliable biomarkers for DNA repair deficiency and could be used to identify patients that would benefit from specific types of anti-cancer therapy.
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FDA Approved PARP Inhibitors

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Rophevac Bio Labz

NABL accredited, dedicated genomics facility for Oncology, Rare Diseases & Reproductive health.

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“It’s our commitment to genomics, Rophevac Bio Labz stands as India’s sole exclusive genomics laboratory.”
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